AMPOULE & VIAL WASHER
option to be part of a compact line or work independently.
and quiet singling out of ampoules in the ultrasonic bath.
quality of ampoule cleaning due to elimination of energy absorbing
transfer components in the ultrasonic bath.
and simple cleaning of recycling water tank through a large opening
at the tank bottom.
change-over due to less sized parts.
parts of the machine that come into contact with the cleaning media
are made of stainless steel. All surfaces coming in contact with the
ampoules / vials are manufactured of stainless steel or specially
selected plastic materials. The stainless steel parts are additionally
hard chromed to give a smoother surface and make it less susceptible
infeed and discharge are opposite each other, clearly separating the
ampoule infeed from the cleaning process. The jetting media are fed
through separate pipes to the jetting stations.
- In order
to reduce water consumption an easily accessible recycling station
is installed inside the machine. The drive is infinitely adjustable.
ampoules / vials can be fed directly from the suppliers cartons
into the infeed chute. From there, passing under a shower head, they
are immersed in the heated ultrasonic bath. In the water bath the
ampoules / vials are singled out into reciprocating lanes. The individually
positioned ampoules / vials are pushed into the cones of the centering
bar by pushers and then fed directly on to the jetting needles. The
jetting wheel works intermittently and feeds the ampoules to the jetting
stations in the upper station.
ampoules / vials are blown of the jetting needles and lifted into
the discharge tray. At this point the ampoules can be either trayed
or fed directly on to the conveyor belt of the sterilizing tunnel.
LINEAR VIAL WASHER
provides 4 water washes & 3 air washes.
flexibility with user for washing cycle.
for washing of Vials (2ml to 30ml)(dia. 14mm to 38mm).
Contact parts made out from SS 316. Entire frame covers & non
contact parts made out from SS 304.
enter into the container during washing cycle to meet cGMP requirement.
change over with minimum use of tools.
fed from the decartoning station (optional)are received on a unscrambler
through Visual Inspection Unit (optional). An infeed worm inverts
container to neck down position and feeds them through a specially
designed indexing device carries the container forward and stops.
carrier enters into the container and activates the jet of water /
air. The air / water flow is deactivated after the washing cycle is
indexes the vials for next wash.
- A separate
pumping station (optional) gives the right quantum of water at the
In the absent of separate pumping station we can provide the recirculation
& siliconization system on request.
containers are again inverted to neck upward position to collect in
trays / directly feed to tunnel.
type Centrifugal Pump.
1 Recirculatory water INT + EXT
2 Recirculatory water INT
3 Fresh water INT + EXT
4 Fresh water INT
5 Air INT + EXT
drive fitted with frequency invertor for variable speed adjustment.
housing with polypropylene filter elements 20 micron, 250mm long
for recirculated water.
housing with polypropylene filter elements 5 micron, 250mm long
for fresh water from loop.
free compressed Air Filter Domnick Hunter for sub-micronic retention
upto 0.1 micron. (Pre-filtration down to 5 micron & the pressure
regulator to be provided by buyer)
Switches with regulator.
solenoid operated valves.
switch for water tank.
station with unscrambler at infeed to washer.
outfeed mechanism, with loading device to tunnel conveyor.
Zone Construction: Drying, sterilizing, cooling & stabilizing
zones. The drying, cooling and stabilizing zones is minipleat patented
GRADVEL separator less HEPA filters, with supply air to the modules
taken from the room and most of the air quantity exhausted. The sterilizing
zone is a recirculatory module with patented Hot minipleat separator
less HEPA filters, with Incoloy heater elements placed in the air
structural elements in duly passivated steel. Air containment and
container contact parts including wire link conveyor is in S.S.304
External paneling in S.S.304.
Temperatures plus 330 deg. C with container temperatures reaching
280 deg. C. Minimum Endotoxin reduction of log 3.
pressure is monitored in drying, sterilizing and cooling zones on
individual Magnehelic pressure gauges.
drive fitted with frequency invertors for variable speed adjustment.
- A fully
wired control panel in S.S.304 cabinet, with PLC controls, and temperature
plotting on an 80-column printer.
tunnel is suitably integrated at the in feed with washer & at
the out feed with filler sealer.
304 Biophragm on Sterilizing Tunnel for sealing sterile zone from
non-sterile zone. Magnehelic differential pressure gauge for over-pressure
monitoring across the filling room.
unscrambler dia 600 mm with SS 304 contact surface, with mechanically
variable speed drive, resulting in single line feed to the delrin
conveyor of the filter-bunger.
Purpose : Storage / Mixing.
a. Working - 300/400.
b. Gross - 360/480.
a. Shell - SS 316.
b. Jacket - SS 304.
(Test Pressure 1.5 times the Working Pressure)
a. Shell - 2.0 kgs/cm2.
b. Jacket - 2.0 kgs/cm2.
Between Shell & Jacket
: 40 mm.
(Bolting Type) : 4 Nos.
a. Material : SS 304.
b. Legs : Round Flange to be provided with 4 Nos. Holes.
(i) Turbo for Mixing Tank :
a. Speed Single Speed.
b. Mechanical Seal Cartridge Type Double Acting Mechanical Seal With
flow Switch For Cooling,
c. Surface TC/TC.
d. RPM 1440
Propeller For Syrup Preparation :
a. Speed Fixed.
b. Mechanical Seal Cartridge Type Double Acting Mechanical Seal With
flow Switch For Cooling.
c. Surface TC/TC.
d. RPM 960.
membrane holders in combination with membrane filters are used for
sterile filtration of pharmaceuticals and biological solutions. On
a production scale either a 290 mm or a 142 mm dia. holder is used.
The selection of the holder depends upon the volume of the liquid
to be filtered in a day. Both the 293 mm dia. and 142 mm dia. holders
are made of SS 316 and are supplied with removable legs. The filter
support screen is offered in SS with polished surface. The inlet and
outlet connections are of sanitory triclover design on larger model
holders for cleaning and maintenance. All these holders are provided
with air vent valves. This valve has to be opened to release any air
that could be trapped in between and may offer resistance to the flow
of the liquid during the process of filtration.
sealing rings can be offered in silicon and grip knobs are provided
to tighten them. The membrane filter support screen has an under drain
- A flow
deflector under the top plate ensures even distribution of the liquid
flow. A back pressure support screen may also be supplied to protect
the filter against reverse accidental flows (Always use a prefilter
while using back pressure screen).
Point Test is a non-destructive test to check the integrity of the
membrane filter, before and after the filtration. The bubble point
is the pressure required to force air through the pores of a wet filter.
If a membrane can not withstand the pressure below bubble point level,
it indicates peak in the filter. A built-in system for bubble testing
can be provided with the membrane holders by in -building a set of
liquid and air control valves.
/ Inline Filter Holders
sterilizing small volumes of liquids, Small size membrane filter holders
are available in three sizes, viz. 13 mm, 25 mm & 47 mm. All holders
are made of SS 316 with silicon sealing gaskets and SS filter support
- A 47
mm membrane filter is installed in a suitable holder. The liquid sample
is drawn through this sterile membrane filter to concentrate any contaminating
micro-organisms on the filter surface. After filtration is completed,
sterile flushing fluid is passed into the funnels, rinsing all sample
residue through the filters so that it cannot possibly inhibit growth
of the retain micro organisms. After this, the filter is sectioned
and asceptically transferred to media for culturing. If growth is
not visible after the incubation period, the sample passes the test.
Place and three place test units are available to simultaneously filter
five or two test samples, respectively with a concurrent control filtration
of sterile diluting fluid for an immediate overall verification of
system sterility. The sterility testing manifolds are made out of
SS material. The entire unit can be autoclaved. Essential parts of
the units are a combined manifold for vacuum and flushing, filter
holders and three way valves.
vessels are manufactured from High Alloy Stainless Steel AISI 316
joints are tig welded. Gaps & dead corners are reduced to an absolute
interior and exterior of all vessels are mirror finished.
- A long
tube is provided to ensure complete drawing for fluid.
vessels can be put in an autoclave and be steam sterilized.
up to 20 ltrs. are provided with hand wheel type covers and on higher
capacity models, flange cover with wing nuts are provided.
vessel is tested at 6 kg /cm2 pressure.
- A pressure
relief valve is provided.
models are available upto 200 ltrs. capacity. Higher capacity units
can also be fabricated.
- SS Mobile
Trolley for easy movement, can also be provided.
vessels are manufactured from high alloy stainless steel (AISI 316)
joints are tig welded. Gaps and dead corners are reduced to an absolute
exterior and interior of all vessels are mirror finished
- A long
tube is provided to ensure complete drawing of the fluid.
vessels can be put in an autoclave and be steam sterilized.
- An air
tight lid with a sight glass is provided.
- A sterile
vent filter can be supplied with the unit as an accessory.
models are available between 20 to 200 ltrs.
- SS mobile
trolley for easy movement can also be provided.
FILLING & SEALING MACHINE
accuracy with enhanced flexibility.
productivity due to reduced idle time and optimization of operating
precision ensured as innovative designed.
technique used for manufacture of major parts.
variable speed to achieve optimum production.
replaceable change parts with minimum setting time to accept different
sizes of ampoules.
and instant off-loading from the moving rack as the machine stops.
and convenient access to controls.
- A backlit
display for production, machine speed, and machine stop.
- No spillage
of liquid if ampoule is missing from filling station.
of ampoules from infeed conveyor to moving rack with the help of a
worm and a segment at very high speed without breakage.
operation even by an inexperienced operator.
All controls through a Programable Logic Controller
conveyor is to be fed with ampoules out of magazines, or directly
from a pre-connected machine.
ampoule loaded on to a conveyor belt are fed to a screw conveyor in
the upright position. The screw conveyor transports the ampoules on
to a segment wheel to be carried on to a conveying cradle. The conveying
cradle carries the ampoules step by step through the stations in the
25,000 ampoules per charge.
Rectangular High pressure - High Vacuum, Steam Sterilizer having chamber
size. Suitable for working pressure of 16 / 18 psig (121deg. C temp.).
The unit will have chamber in S.S. 316 with a double-hinged door in
S.S. 316 construction.
will be designed to sterilize non-porous loads. It will be used for
terminal sterilization of filled ampoules. This sterilizer will have
spray water arrangement for quick cooling of the load at the end of
jacket will be of SS. 304 sheet insulated with ceramic blanket and
finished with SS. 304 cladding. The unit will be complete with standard
fittings such as pressure gauge, compound gauge, dial thermometer,
safety valve, condensate discharge line with steam trap and ports
for 5 temperature probes, pneumatic safety locks, along with a 1"
Validation Port. The control panel is in S. S. 304 and fitted with
PLC / Microprocessor.
- 80 -
column printer, electrically operated with 5 Pt - 100 probes mounted
at suitable locations all over the autoclave, duly connected to printer.
pressure reducing station for steam, complete with strainer, non-return
valve and pressure gauge.
system consists of 10" long sintered SS. 316L element of 20 micron
prefilter & 5 micron final filter with suitable housings in S.
filter for vacuum break with sterile air into the chamber, with filtration
down to 0.3 micron having ½" BSP (male) connection and
suitable SS piping to the vent port on the autoclave.
loading cage will be in S. S. 316 framework with rolling wheels and
S. S. Angles for four adjustable shelf. - 1 No.
- S. S.
304 Transfer cart with railing and suitable locking arrangement. -
2 Nos. SS 316 Solenoid Valve for Vacuum Pump.
and continuous clean down of working area.
areas in the clean air work environment avoided by elimination of
picture frame effects and induction leakage - a result
of Superior Engineering Inputs.
and noise levels well below specified limits - a result of carefully
balanced motor blower assembly with special bearings and a unique
construction, adaptable to incorporate a variety of optional features
and ancillary equipment to meet application needs.
construction resulting in long, trouble free services.
performance tests on each LAF unit prior to dispatch, ensuring conformity
with international standards.
and effective after sales Support, including continual validation.
independent floor-standing unit is the most favoured designed for
microbiological manipulations, bio-assays, sterility testing and research
in allied fields ; Semi automatic vial filling and bunging operations
in parenteral production ; hospitals, pathological laboratories ;
microelectronics, optics, and general dry-processing work in semi
conductor manufacture ; research and development work ; food and beverage,
agriculture, animal husbandry, aerospace and avionics.
flow pattern is favoured for dry processing applications in semiconductor
manufacture ; automatic filling lines in parenteral production ; investigative
work with mildly toxic materials in microbiological and other research
control laboratories ; protection for open vessels of chemicals, solvents
or powder ; general assembly work.
& HEIGHT ADJUSTABLE
Inclinable and Height Adjustable configuration :
This simple and portable unit produces a unidirectional flow
clean air space at an inclination over the work area the angle
of flow is adjustable for optimal orientation.
Duplex Configuration : This exclusive TWIN horizontal Laminar
Flow unit, available also in standard version has been designed
to provide an economic means of countering contamination control
problems with optimal utilization of valuable floor space.
Deluxe Configuration : This immaculately profiled and carefully
designed configuration is popular because of the inbuilt storage
cabinet facility and rugged maintenance free, all wood melamine
Slim Configuration : This unit with motor blowers are pre-filtered
on one side, and access panel for HEPA filters on the other, is
also preferred for powder handling by incorporating a return air
plenum connected to the pre-filters.
/ VIAL INSPECTION MACHINE
contact parts expects the rack are made from SS 304.
are provided with acrylic covers with grooves to detect cracks, charring
etc. on mouth of the ampoules / vials.
ejection system occupies very little space.
of spinners can be adjusted to give desired vortex on liquid.
quality lens reduces operator eye strain.
breakage of ampoules / vials due to adequate bearing points on spinners.
access for cleaning and maintenance.
transport time as compared to inspection time.
of repeat cycle.
filled ampoules / vials are loaded into the infeed chute from where
they are transferred in batches by an index wheel onto a linear transfer
rack transfers the ampoule / vials on to the inspection station, where
spinners spin the ampoules / vials at a predetermined RPMso that a
vortex is formed. Light coming from behind the ampoules / vials magnifies
all particles / fibers with the help of the lens.
ampouleb / vials are rejected by pressing rejection switches ergonomically
located for the operator convenience. A numbered light kept just above
the magnifying lens within the operators field of vision lights
up indicating the ampoules vials which have been rejected.
- In case
a recheck is desired before checking the next lot, a facility for
repeat cycle is provided.
ampoules / vials batch is then transferred onto the rejection station
where the ampoule / vials rejected at the inspection station are automatically
rejected out. A number light lights up above the lens indicating a
positive rejection taking place.
accepted ampoules / vials are transferred on to the collection station
where they are collected in the tray.